Job Description

The dos Santos laboratory in the Department of Oncology at St. Jude Childrens Research Hospital is seeking a highly motivated postdoctoral research associate to investigate the cellular and molecular mechanisms that regulate mammary gland biology and breast cancer susceptibility.

Research in the dos Santos laboratory focuses on how genetic predisposition interacts with systemic and tissue-level factors including inflammation infection pregnancy aging and hormonal changes to influence mammary epithelial cell identity the tissue microenvironment and breast cancer initiation. Our studies integrate genetically engineered mouse models primary mammary organoids human biospecimens single-cell genomics epigenomic profiling spatial and tissue-imaging approaches and functional perturbation experiments.

The successful candidate will lead an independent but highly collaborative project examining mechanisms of breast cancer initiation and progression.

Potential research directions include:

• Defining how systemic inflammatory and physiological signals alter mammary epithelial cell states and breast cancer susceptibility.
• Investigating interactions among epithelial cells fibroblasts immune cells and the extracellular matrix during early tumorigenesis.
• Identifying mechanisms that promote lineage plasticity in BRCA1-deficient and other genetically susceptible mammary tissues.
• Examining how pregnancy aging and hormonal transitions affect mammary tissue organization and tumor risk.
• Developing organoid and in vivo models for mechanistic studies and cancer-interception strategies.
• Investigating the molecular and cellular basis for increased breast cancer risk in Childhood cancer survivors

Key Responsibilities

• Design conduct analyze and interpret independent research projects.
• Use genetically engineered mouse models mammary transplantation assays organoid systems and mammalian cell culture.
• Perform molecular cellular imaging and functional assays relevant to mammary gland and cancer biology.
• Collaborate with computational scientists to analyze single-cell RNA-seq ATAC-seq spatial and other genomic datasets.
• Maintain rigorous and reproducible experimental records.
• Present findings at laboratory meetings institutional seminars and national or international conferences.
• Prepare manuscripts fellowship applications and research proposals.
• Mentor graduate students research staff and other junior laboratory members.
• Contribute to a rigorous collaborative inclusive and intellectually engaging laboratory environment.

Qualifications

• PhD MD MD/PhD or equivalent doctoral degree in cancer biology molecular biology cell biology developmental biology genetics immunology bioengineering computational biology or a related discipline.
• Strong record of scientific productivity and evidence of independent research ability.
• Experience with at least one of the following: mouse models organoid culture molecular and cellular biology microscopy flow cytometry single-cell genomics epigenomics or computational analysis.
• Strong quantitative organizational written and oral communication skills.
• Ability to work independently while contributing effectively to collaborative projects.
• Commitment to rigorous reproducible and ethical research.

Applicants with complementary expertise in immunology stromal biology developmental biology aging metabolism bioengineering or computational genomics are strongly encouraged to apply.

Research Environment

The dos Santos laboratory is located within the Department of Oncology at St. Jude Childrens Research Hospital in Memphis Tennessee. St. Jude provides an exceptional multidisciplinary research environment with state-of-the-art shared resources in animal modeling organoid biology flow cytometry advanced microscopy single-cell and spatial genomics proteomics computational biology genome engineering and biostatistics. The successful candidate will receive close scientific mentorship and support in developing an independent research identity. Opportunities are available for interdisciplinary collaboration professional development conference participation fellowship applications manuscript preparation and career advancement in academic clinical biotechnology or pharmaceutical research.

Application Instructions

Interested candidates should submit:

• A cover letter describing their research experience scientific interests and reasons for joining the dos Santos laboratory.
• A current curriculum vitae.
• A brief summary of previous research accomplishments and future research interests.
• Contact information for three professional references.

Applications should be sent to Dr. Camila dos Santos at with the subject line Postdoctoral Application Applicants Name.

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Required Experience:

IC

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